How reported history of traumatic brain injury correlates with various aspects

 
   Lead Investigator:    Hsueh-Sheng Chiang
   Institution      :    University of Texas at Dallas
   E-Mail           :    hschiang@utdallas.edu
   Proposal ID      :    628



   Proposal Description:
   1) We examine whether reported history of traumatic brain injury (TBI) can         affect disease onset and severity in autopsy-confirmed Alzheimer's Disease. We    expect that TBI can not only shorten the onset of dementia but also increase      the severity of AD-related symptomatology and pathology.                          2) The majority of the literature has been based on clinical diagnosis of AD but   not proven by autopsy. We examine autopsy-confirmed AD to offer more definite     evidence of how TBI may affect AD. The impact of TBI on the clinical course and   severity of AD can thus be more clearly characterized.